In order to solve the problem of node voltage fluctuation when high proportion of distributed power is connected to the distribution network, this paper presents an active and reactive power cooperative optimal control strategy considering intelligent soft switch. Firstly, the factors affecting the voltage fluctuation of nodes are analyzed, and the voltage can be controlled from the Angle of active power and reactive power, and the working principle of intelligent soft switch is analyzed. It can precisely control the active power transmitted between the feeder lines connected on both sides and provide a certain reactive power. Secondly, a mathematical model of active and reactive power optimization of distribution network with minimum loss and minimum voltage deviation as objective functions is established, which is transformed into a single objective model by weight coefficient. Thirdly, the model is solved by improving the grey Wolf algorithm. Finally, the simulation verification is carried out on the IEEE33 node system. The results show that the proposed strategy can reduce the voltage fluctuation and network loss effectively.