In order to study the dynamic response of steel frame structures to continuous collapse under fire. Through ABAQUS finite element software, the dynamic test of two story four span plane steel frame with instantaneous column removal and the fire test of plane steel frame are simulated. By comparing the vertical displacement time history curve and failure mode obtained from numerical simulation with the test results, the accuracy of the finite element model is verified, and the displacement temperature curve obtained also verifies the applicability of the sequential thermal mechanical coupling method. On the basis of verifying the validity of the finite element model, the dynamic response of steel frame structures with instantaneous column removal under different fire temperatures against continuous collapse is further studied. The research shows that: when the connection forms of different joints remove the columns instantaneously, the failure mode of the steel frame and the stability of the structure have a significant impact. When the steel frame adopts reinforced joints under high temperature of fire, the frame columns are more prone to excessive buckling, which is more likely to cause continuous collapse; The higher the temperature is, the higher the peak displacement value and the vertical displacement value of the middle column node of the steel frame after removal of the column are. The more obvious the structural dynamic response is, the smaller the structural resistance to continuous collapse is.