The safety of pipeline projects running through mountainous areas will be threatened by landslides. In recent years several accidents occurred, lots of casualties and economic losses occurred with the accidents. Two landslides pipe breakage accidents of the China-Myanmar natural gas pipeline (Qinglong Section, Guizhou Province) happened in 2017 and 2018，in this paper we took it as examples. It combined with geological environment conditions and on-site accident investigation data, based on the finite element solid contact model, studying of the occurrence process inversion of the two accidents. To analyze the force and deformation characteristics of pipeline under the action of landslide. It will confirm the accident cause. The results show that the deflection deformation of the pipeline presents nearly normal distribution under the action of landslide, and the stress at the middle and boundary of the pipeline is relatively the largest and it’s easy to be destroyed. The accumulation of soil above the slope where the pipeline is located causes the pipeline to produce large axial tensile stress, which is easy to produce brittle crack damage at the pipe body or girth weld defects, and then cause gas leakage and explosion. Therefore, the pipeline should be avoided engineering disturbance during the later maintenance of the pipeline, especially a large amount of soil piled above the slope. It would prevent threats to the operation safety of the pipeline.