It is of great significance to study on the fatigue failure resistance of section fire doors for eliminating potential safety hazards in the actual project operation stage. In this paper, simplified numerical model of fire door and refined model considering the contact relationship are established based on ABAQUS finite element software, the accuracy of the model is verified by the performance measurement test of fire door. The stress state of each component of fire door under constant and reciprocating wind pressure is studied by the model. According to the research results, the fatigue life of fire door under reciprocating wind pressure is predicted. The results are obtained as follows: under the condition of reciprocating cyclic load, the high stress area of the fire door is mainly concentrated in the connection area between the door lock and the hinge and the door body; The predicted cycle life at the predicted locking point is 3.69×105 times, the predicted cycle life at the hinge is 1.3×106 times, the fatigue life of other parts of the door body is more than1×108 times.