Multi-objective aerodynamic/noise optimization design for a large-sized propeller was carried out. Based on the lifting surface theory, the propeller aerodynamic performance calculation was carried out, and the accuracy of the calculation method was verified by comparing with the experimental results. Based on the Hanson frequency domain far-field noise calculation method, the propeller far-field noise assessment was evaluated. The chord length, installation angle, bend and sweep of the propeller blade along the span-wise distribution were regard as design variables. The number of propeller blades, radius and speed was not changed. The optimization goals were set as no reduction of the aerodynamic performance and the maximization of the far-field noise reduction. The optimized design results were compared with the high-precision calculation results. The optimization results show that, without reducing the aerodynamic performance of the propeller, the far-field aerodynamic noise of the optimally designed propeller is reduced by 5 dB at the first-order discrete components, and the second-order and third-order discrete components are also reduced.