A large amount of fog is generated during the shovel loading operation point in open-pit mine in winter, which blocks the driver’s view, reduces mining and loading efficiency. Considering the actual situation and comparative analysis, the compressed air jet is proposed to disperse the fog. An open-pit mine was taken as the research object, a compressed air jet fog dispersal model of the shovel loading operation point in open-pit mine was established, using ANSYS Fluent to simulate the influence of outlet wind speed, fan installation number and installation angle on fog dispersal effect of compressed air jet. The results show that two compressed air jets with outlet wind speed of 39.7 m/s can drive fog more effectively, and when the two compressed air jets are installed at an internal angle of 15°, the fog dispersal effect is well. The scheme was applied in the open-pit mine, the fog dispersal effect is obvious and the shovel driver‘s line of sight is improved. It can provide technical support for fog dispersal in winter at shovel loading operation point in open-pit mine in winter.