While the horizontal well spacing is short, the fracturing fractures between adjacent wells will collude with each other, resulting in well interference and affecting the development effect. At present, the research on well interference in horizontal wells prevailingly focuses on horizontal interference, while the longitudinal well interference is rarely involved. The tight sandstone reservoir of the Montney Formation in the Canadian Groundbrich Project is 210 m thick and contains seven continuous layers in the longitudinal direction. It is found that there is severe longitudinal well interference when using 3 well patterns by using production performance analysis method. In this regard, 3 sets of development layer are adjusted into 2 sets of development layer by absorbing the development experience of similar gas fields at home and abroad and deeply analyzing the geological and development characteristics of Groundbrich tight sandstone gas reservoir. Through comprehensive comparative analysis of development effects of different development layer combinations, it is found that compared with 3 sets of development layer, the average estimated ultimate reserve (EUR) of staged fractured horizontal wells in B, C and E layer with 2 sets of development layer increases by 61%, 89% and 42% respectively when the length of horizontal section is normalization to 1 000 m, and the development effect is greatly improved. The results show that the adjustment of longitudinal development layer combination is beneficial to the efficient development of Groundbrich tight sandstone gas reservoir.