It is of great significance to master the viscosity characteristics of crude oil-water mixture with high water fraction for pipeline transportation of oil-water system with high water fraction. The effects of shear rate, water fraction, temperature, content of single surfactant, content of combinatorial surfactants on the apparent viscosity of crude oil-water mixture with high water fraction were measured and studied by stirring method. The results showed that the apparent viscosity of mixture decreased with the increase of shear rate, water fraction and temperature, showing a property of shear thinning, and this property gradually decreased with the increase of temperature or water fraction. The apparent viscosity of mixture did not vary with the content of single surfactant, such as asphaltenes, resins, waxes and mechanical impurities, but gradually increased with the increase of the content of combinatorial surfactants. The apparent viscosity of mixture was not dependent on any single surfactant, but was closely related to the total content of the representative surfactants in crude oil, and was influenced by the synergistic effect of various surfactants. By regression analysis, the viscosity calculation model of crude oil-water mixture with high water fraction was established, and the average relative deviation of the model calculation results was 7.8%.