Serve as promotion reasonable medicine treatment, randoml withdrawal of 1 525 prescription of drugs coming from 500 elder patients between January to June in 2004 , according to directions of drugs, clinical pharmacological knowledge and literature data, unreasonable prescription of drugs are analyzed. Unreasonable prescription of drugs in those prescription of drugs standed up 3.92 percent including usage, dosage, duplication, medicine antagonism and uncompatibility of medicine. It is conclused that combination treatment for elder patients should be used carefully, pharmaceutists should instruct actively drugs treatment.