Through the November 29, 2015 - December 3 a real-time haze, cold weather process and the simulation process of the cold weather(Completely ruled out the influence of haze) and PM2.5 effect on atherosclerosis rats contrast experiment research,To discuss Haze and cold air joint action mechanism of the effect on cardiovascular disease. Will be 24 healthy male rats were randomly divided into four groups, each group of 6, and made into atherosclerosis model rats, respectively, haze and the cold weather group (Natural group), simulation of cold air influence group (Simulated group ), PM2.5 impact group (PM2.5 group) and control group in four groups. Using three kinds of forms to affect exposure respectively, First is made according to the hebei province meteorological observatory weather and air quality forecast, on November 29 - December 3, 2015 for haze and cold weather process in real time to expose the influence of natural group, Simulation case simulation application TEM1880 meteorological environment on November 29, 2015 - December 3 empty cold weather process of simulating the effect of group, Three is to November 27, 2015 - December 3 collection of PM2.5 particles, suspended solution, give PM2.5 group of trachea drip into the exposed to the influence of PM2.5 suspension solution. Test each physiological indexes such as heart rate, blood pressure and anus temperature, and abdominal aortic blood and gather the apex homogenate, measuring between groups atherosclerosis rats oxidation factor（T-SOD、GSH）, inflammatory factors（IL-6、hs-CRP、TNF-α、sICAM-1） and cardiovascular risk factors（ET-1、NE、EPI、AngⅡ）, vasoconstriction factor and reaction of thrombosis factor(D-dimer、PAI-1）of biochemical indexes of content. Results show that atherosclerosis rats by haze and cold air from the combined impact of all the physiological and biochemical indexes than the cold air or PM2.5 significantly affect change alone, haze interact with cold air, cold air exacerbated the haze of the coronary artery and heart toxicity, aggravate cardiovascular disease significantly, even lead to sudden death of acute myocardial infarction , preliminary explored the haze and cold air joint action of the mechanism of the effect on cardiovascular disease.