Continuous supercritical water oxidation was used to treat with wastewater from production of chlorpyrifos. Studied four factors of chlorpyrifos production wastewater treatment effect such as the reaction temperature, pressure, residence time and the oxygen multiples.The results show that the temperature, pressure, residence time and the oxygen multiples are impact on pollutants of supercritical water oxidation process, the temperature effect on organic nitrogen transformation is the most significant, temperature higher than 450 ℃, organic nitrogen into completely, the removal rate of COD, TN is greater than 99% and 90% respectively, and the removal efficiency of ammonia nitrogen conversion reaction conditions are harsh, combined with simultaneous denitrification technology, can realize high removal of COD and ammonia nitrogen pollutants and emissions standards.