With the acceleration of urbanization, urbanization process will inevitably lead to changes in land use types, changes in land cover occur will have a huge impact on the surface energy of the region, the air flow field characteristics, atmospheric turbulence characteristics of meteorological elements, etc. impact the material transport within the region of atmospheric diffusion process impact, furthermore. In this paper, with the urban canopy schemes coupled to WRF model, some numerical experiments are employed to investigate the impact of land-use change on local thermodynamic circulation. The land cover of Nanjing city in 1993 and 2010 are taken as examples. The simulation results show that 2m temperature in urban region increases from 1993 to 2010, and the addition of temperature can reach 3K at 24:00. Results show that urbanization weakens the wind and enhances the pollutant trapping and therefore contributes to the overall poor air quality in the region. Urban heat island leads to the convergence of airflow in the lower layer of atmosphere, With more urbanized region, stronger turbulent kinetic energy(TKE), for example the maximum of TKE at noon increased from 2.1 m2.s2 to 2.7 m2.s2. Urban sprawl enhances vertical mixing and hinders horizontal downward dispersion which caused pollutants to accumulate in urban areas.