Xiaojiang River Basin is characterized by steep terrain, complex geological conditions, strong earthquake and Neotectonic activities, and complex climate and hydrological conditions, which lead to the development of landslides and other mountain disasters. Landslides in the basin are not only numerous, but also frequent, which seriously threaten the safety of people's lives and property and social and economic development. In this study, the slope unit divided by the surface curvature watershed method is used as the evaluation unit. Based on the frequency ratio method, eight influencing factors including slope, aspect, curvature, relative height difference, lithology, seismic peak acceleration, fault zone density and river network density are calculated to evaluate the contribution of landslide development in Xiaojiang River Basin, and the landslide is obtained by superposition analysis based on ArcGIS software Sensitivity zoning map. Through the verification of the results, 132 landslides were developed in high and extremely sensitive areas, accounting for 79.04%, with high accuracy. The relevant research results can provide a theoretical basis for the emergency management of disaster prevention and mitigation in Xiaojiang River Basin, and have important practical significance for the development planning and sustainable development of the region.